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Updated: Feb 1, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

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Potential Drug-drug Interactions at a Referral Pediatric Oncology Ward in Iran: A Cross-sectional Study

Faezeh Tavousi1, Alireza Sadeghi2, Ali Darakhshandeh2

  • 1Departments of Clinical Pharmacy.

Journal of Pediatric Hematology/Oncology
|December 12, 2018
PubMed

Insights

Drug-drug interactions (DDIs) are common in pediatric cancer patients, with pharmacodynamic interactions being most frequent. Age, sex, and medication number influenced DDI occurrence, highlighting the need for further research.

Area of Science:

  • Oncology
  • Pharmacology
  • Pediatrics

Background:

  • Drug-drug interactions (DDIs) are frequently reported but understudied in pediatric oncology.
  • Understanding DDIs in this vulnerable population is crucial for patient safety.

Purpose of the Study:

  • To determine the frequency and demographic factors associated with moderate and major DDIs in pediatric oncology patients.
  • To identify common drug classes involved in DDIs within this patient group.

Main Methods:

  • A 6-month study (2017) at a pediatric oncology ward included 115 patients receiving at least two concomitant medications.
  • Potential DDIs were identified using Lexi-Interact software.
  • Data on patient demographics and drug classes were collected.

Main Results:

  • 194 moderate or major DDIs were detected among 115 patients.
  • Pharmacodynamic interactions accounted for 56.4% of DDIs.
  • Corticosteroids, antimetabolites, and antiemetics were the most frequent medication classes involved.
  • Aminoglycosides and third-generation cephalosporins showed the most common non-anticancer DDI; doxorubicin and cyclophosphamide were the only anticancer DDI pair.
  • Age, sex, and number of medications correlated with DDIs.

Conclusions:

  • Moderate to major DDIs are frequent in pediatric cancer patients.
  • Further studies are needed to evaluate the clinical and economic impact of these DDIs.

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