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Antibody-drug conjugates for ovarian cancer: current clinical development

Daphne Stewart1, Mihaela Cristea

  • 1Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, California, USA.

Current Opinion in Obstetrics & Gynecology
|December 12, 2018
PubMed
Abstract

Insights

Antibody drug conjugates (ADCs) offer targeted cancer therapy, showing promise for platinum-resistant ovarian cancer. Mirvetuximab Soravtansine demonstrates efficacy in FRα-positive patients, with other ADCs in early trials.

Area of Science:

  • Oncology
  • Pharmacology
  • Biotechnology

Background:

  • Antibody drug conjugates (ADCs) represent a novel therapeutic strategy for cancer treatment.
  • ADCs deliver cytotoxic payloads directly to cancer cells, minimizing off-target toxicity.
  • Platinum-resistant ovarian cancer remains a significant clinical challenge.

Purpose of the Study:

  • To review the current landscape of antibody drug conjugates (ADCs) in clinical development for ovarian cancer.
  • To highlight the potential of ADCs in overcoming chemotherapy resistance in ovarian cancer.

Main Methods:

  • Summary of ADCs currently in clinical trials for ovarian cancer.
  • Review of specific ADC agents, including their targets and preliminary efficacy data.

Main Results:

  • Mirvetuximab Soravtansine shows promising activity and a favorable toxicity profile in FRα-positive, platinum-resistant epithelial ovarian cancer (EOC).
  • Antitumor effects of Mirvetuximab Soravtansine are most notable in patients with moderate-to-high FRα expression and less prior treatment.
  • Additional ADCs targeting NaPiB2, Trop2, mesothelin, and MUC16 are in early-phase clinical trials for ovarian cancer.

Conclusions:

  • ADCs hold significant potential to improve treatment strategies for ovarian cancer by enhancing efficacy and reducing toxicity.
  • Appropriate antigen selection and target threshold definition are crucial for successful ADC therapy in ovarian cancer.
  • The development of novel ADCs represents a promising avenue for managing platinum-resistant ovarian cancer.

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