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Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget
Published on: November 20, 2018
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Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget
Jiyeon K Denninger1, Bryon M Smith1, Elizabeth D Kirby2
1Department of Psychology, Ohio State University.
Journal of Visualized Experiments : Jove
|December 12, 2018
Summary
This study presents a cost-effective method for mouse behavioral testing using the object location task (OLT) and novel object recognition task (NORT) to assess memory and brain function.
Area of Science:
- Neuroscience
- Animal Behavior
- Cognitive Science
Background:
- Mouse models are crucial for studying cognitive changes.
- Object location task (OLT) and novel object recognition task (NORT) assess memory.
- These tasks require specialized, often costly, equipment.
Purpose of the Study:
- To detail a simple, cost-effective method for building arenas and setting up equipment for OLT and NORT.
- To describe an efficient protocol incorporating both OLT and NORT.
- To provide methods for data acquisition, analysis, and representative results.
Main Methods:
- Construction of cost-effective open-field arenas.
- Setup of video recording equipment and software.
- Implementation of an integrated OLT and NORT protocol.
Main Results:
- Demonstration of a feasible and economical approach to behavioral testing.
- Presentation of a standardized protocol for OLT and NORT.
- Provision of typical data acquisition, analysis, and representative results.
Conclusions:
- This method enables valuable insights into memory function in mouse models.
- It facilitates the appraisal of neural regions supporting memory.
- Offers a budget-friendly alternative for cognitive behavioral testing in rodents.
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