Related Experiment Video

Updated: Feb 1, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

[Long-term outcomes of spinal neurostimulation in patients with critical lower limb ischemia]

A S Klinkova¹, O V Kamenskaya¹, A V Ashurkov¹

¹Meshalkin National Medical Research Center of Healthcare Ministry of Russia, Novosibirsk, Russia.

|December 12, 2018

Abstract

Aim:

To evaluate long-term outcomes of spinal neurostimulation (SNS) in patients with critical lower limb ischemia (CLI).

Material And Methods:

Long-term outcomes of SNS were assessed in 52 CLI patients. Changes of clinical status were considered by using of Rutherford R.B. et al. scale. Before and in 12 months after SNS percutaneous oxygen partial pressure (TO₂, mm Hg) was measured at the affected lower limb at rest and in orthostatic test. Ankle-brachial index (ABI) was also determined.

Results:

SNS improved clinical status in most cases through following effects: 1) reduced pain syndrome and increased motor activity; 2) skin ulcers healing due to increased TO₂ and improved functional state of microcirculation. No augmentation of TO₂ during orthostatic test at TO₂ <10 mm Hg was associated with negative clinical dynamics after SNS (OR 3.2, CI 2.2-54.1, p=0.002). Coronary artery disease with supra-aortic vessels lesion was associated with reduced ABI after SNS (OR 2.1, CI 1.4-3.8, p=0.001).

Keywords:

lower limb ischemia microcirculation spinal neurostimulation

More Related Videos

Photothrombosis-induced Focal Ischemia as a Model of Spinal Cord Injury in Mice

Photothrombosis-induced Focal Ischemia as a Model of Spinal Cord Injury in Mice

Published on: July 16, 2015

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Published on: June 2, 2019

Related Concept Videos

Critical Region, Critical Values and Significance Level

Critical Region, Critical Values and Significance Level

The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...

Predicting Reaction Outcomes

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...

Critical Values

Critical Values

A critical value is a definite value obtained from a particular probability distribution at a predecided confidence level (or a predecided significance level) for a given population parameter. The critical value provides demarcation that separates the sample statistics that are likely to occur from the ones that are unlikely to occur based on the given probability distribution and the population parameter to be estimated. The critical value for normal distribution is obtained from the z...

Outcomes of Glycolysis

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Critical Thinking I

Critical Thinking I

Critical thinking helps decision-making and allows nurses to recognize barriers to success and find solutions to possible issues. It helps to brainstorm and implement ideas to achieve goals. Critical thinking helps acknowledge and state workflow inefficiencies while improving management techniques. Nurses understand the value of critical thinking and look for fellow nurses with critical thinking skills to upgrade their professional standards. Critical thinking can advance a nurse's career...

Articles linked to this work by shared authors, journal, and citation graph.

[Prevention of postoperative thromboembolic complications in patients with brain tumors].

Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery·2026

[Comparative analysis of endovascular and open surgical treatment of aortoiliac bifurcation lesions].

Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery·2026

[Carotid artery occlusion and stenosis (Russian experts' guidelines)].

Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery·2026

[Distal embolism during endovascular and hybrid reconstruction of extensive occlusion of the superficial femoral artery].

Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery·2026

[Neovasculgen® - has its effectiveness been proven? (Audiatur et altera pars)].

Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery·2026

[Endovascular versus hybrid interventions for steno-occlusive lesions of the iliofemoral segment (a pilot prospective randomized trial)].

Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery·2026

See all related articles