Related Experiment Video
Updated: Jul 10, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Published on: May 11, 2015
The treatment of chronic pulmonary hypertension by vasodilators: hope and hesitation
1Czechoslovak Academy of Sciences, Institute of Physiological Regulations, Prague.
Abstract:
Contemporary therapy of most advanced cases of chronic lung disease is not yet satisfactory; even long-term oxygen treatment has shortcomings and limitations. Many authors have tried to find another therapeutic approach for the correction of either pulmonary hypertension or oxygen delivery, both factors being related to long-term survival. Vasodilators seem to be the subject of further intensive research rather than an established therapy. The results of acute experiments with different drugs are promising but studies of long-term treatment are incomplete. Some of the most pertinent questions for further research are: the classification of the reversibility of pulmonary hypertension, reliable evaluation of the results of therapy, the application of animal experiments to human pathology, haemodynamic conception of an ideal vasodilator, and the attenuation of the effect of some vasodilators during long-term treatment.
More Related Videos
Related Concept Videos
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...

