Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperthermia in cancer therapy.

J Otte1

  • 1Department of Pediatrics, Childrens Hospital, Medical University, Lübeck, Federal Republic of Germany.

European Journal of Pediatrics
|August 1, 1988
PubMed
Summary

Tumor hyperthermia, a rediscovered oncotherapy, shows value in various studies. This article explores its biological basis and use alongside other cancer treatments like radiotherapy and chemotherapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gene expression profiling in aggressive digital papillary adenocarcinoma sheds light on the architecture of a rare sweat gland carcinoma.

The British journal of dermatology·2018
Same author

Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study.

Gene therapy·2016
Same author

Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study.

Gene therapy·2016
Same author

Factors that Influence Mycobacterium bovis Infection in Red Deer and Wild Boar in an Epidemiological Risk Area for Tuberculosis of Game Species in Portugal.

Transboundary and emerging diseases·2015
Same author

An assessment of the feasibility of a poultry tracing scheme for smallholders in Vietnam.

Revue scientifique et technique (International Office of Epizootics)·2012
Same author

Isolation and identification of low molecular weight antioxidant compounds from fermented "chorizo" sausages.

Meat science·2011

Area of Science:

  • Oncology
  • Biomedical Engineering

Background:

  • Hyperthermia is a cancer treatment using heat, with established biological mechanisms.
  • Both direct effects on tumor cells and indirect effects via microcirculation are crucial for its efficacy.

Purpose of the Study:

  • To review the biological basis of tumor hyperthermia.
  • To discuss its application in combination with radiotherapy and chemotherapy.
  • To highlight challenges and future potential as a fourth pillar of cancer therapy.

Main Methods:

  • Review of existing studies on hyperthermia's direct and indirect effects on tumors.
  • Analysis of hyperthermia's role in combination cancer therapy.

Main Results:

  • Hyperthermia has significant direct effects on tumor cell DNA, RNA, protein synthesis, metabolism, and membranes.
  • Indirect effects, mediated by microcirculation changes, are increasingly recognized and important for tumor damage.
  • Combining hyperthermia with radiotherapy and chemotherapy is well-documented and shows increasing significance.

Conclusions:

  • Tumor hyperthermia is a valuable oncotherapy with a solid biological foundation.
  • Overcoming technical challenges in heat application and thermometry is key to its broader use.
  • Hyperthermia holds potential as a fourth major cancer treatment modality alongside surgery, radiotherapy, and chemotherapy.

Related Experiment Videos