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The Evidence for Evolution02:55

The Evidence for Evolution

48.1K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.1K
Convergent Evolution01:54

Convergent Evolution

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Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
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Eukaryotic Evolution01:24

Eukaryotic Evolution

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The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
41.4K
Synteny and Evolution02:31

Synteny and Evolution

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John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.8K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

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Related Experiment Video

Updated: Feb 1, 2026

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
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Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

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Origin and evolution of pathogenic coronaviruses.

Jie Cui1, Fang Li2, Zheng-Li Shi3

  • 1CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China.

Nature Reviews. Microbiology
|December 12, 2018
PubMed
Summary

Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) likely originated in bats. This review explores their evolution, receptor usage, and the potential for bat-borne coronaviruses to spill over into new hosts.

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Area of Science:

  • Virology
  • Zoonotic Diseases
  • Evolutionary Biology

Background:

  • Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are highly transmissible and pathogenic viruses that emerged in humans in the 21st century.
  • Genetic evidence suggests bats as the likely origin for both SARS-CoV and MERS-CoV, with diverse related coronaviruses found globally in bat populations.

Purpose of the Study:

  • To review current knowledge on the origin and evolution of SARS-CoV and MERS-CoV.
  • To discuss the receptor usage of these pathogenic coronaviruses.
  • To highlight the diversity and spillover potential of bat-borne coronaviruses.

Main Methods:

  • Literature review of scientific publications on coronaviruses.
  • Analysis of genetic data related to SARS-CoV, MERS-CoV, and other bat-borne coronaviruses.
  • Examination of studies on coronavirus receptor usage and host-pathogen interactions.

Main Results:

  • Bats harbor genetically diverse coronaviruses related to SARS-CoV and MERS-CoV.
  • Understanding of coronavirus evolution and receptor usage is crucial for predicting and preventing zoonotic spillover.
  • The spillover of swine acute diarrhoea syndrome coronavirus (SADS-CoV) to pigs demonstrates the potential for bat-borne viruses to infect new hosts.

Conclusions:

  • Bats are a significant reservoir for pathogenic coronaviruses with pandemic potential.
  • Further research into bat virology and coronavirus evolution is essential for public health.
  • Monitoring and understanding zoonotic spillover events are critical for mitigating future outbreaks.