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Updated: Feb 1, 2026

Molecular Evolution of the Tre Recombinase

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

Molecular Russian dolls.

Kang Cai¹, Mark C Lipke¹, Zhichang Liu²

¹Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.

Nature Communications

|December 12, 2018

Summary

This summary is machine-generated.

Researchers created novel box-in-box supramolecular assemblies using host-guest radical-pairing interactions between diradical dicationic cyclophanes. These assemblies can encapsulate benzene derivatives, forming hierarchical Russian doll structures.

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Last Updated: Feb 1, 2026

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Area of Science:

Supramolecular Chemistry
Organic Chemistry
Materials Science

Background:

Host-guest recognition and the formation of non-intertwined ring-in-ring assemblies are challenging targets in noncovalent synthesis.
Macrocyclic chemistry offers unique platforms for constructing complex molecular architectures.

Purpose of the Study:

To design and characterize a novel box-in-box supramolecular assembly.
To explore host-guest radical-pairing interactions between diradical dicationic cyclophanes.
To create hierarchical Russian doll-like assemblies incorporating neutral guest molecules.

Main Methods:

Synthesis and characterization of rigid diradical dicationic cyclophanes.
Investigation of host-guest complexation using radical-pairing interactions.
Structural analysis of the resulting box-in-box and Russian doll assemblies.

Main Results:

Successful formation of a box-in-box assembly through radical-pairing interactions between two cyclophanes.
Demonstration of the ability to host 1,4-disubstituted benzene derivatives within the smaller cyclophane cavity.
Creation of hierarchical assemblies resembling Russian dolls.

Conclusions:

The developed box-in-box assembly provides a new platform for supramolecular chemistry.
Matching cyclophane dimensions is an effective strategy for creating hybrid supramolecular assemblies.
This work expands the possibilities for designing complex, multi-component supramolecular structures.