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Updated: Feb 1, 2026

A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
A data augmentation approach for a class of statistical inference problems
Rodrigo Carvajal1, Rafael Orellana1,2, Dimitrios Katselis3
1Electronics Engineering Department, Universidad Técnica Federico Santa María, Valparaíso, Chile.
Abstract:
We present an algorithm for a class of statistical inference problems. The main idea is to reformulate the inference problem as an optimization procedure, based on the generation of surrogate (auxiliary) functions. This approach is motivated by the MM algorithm, combined with the systematic and iterative structure of the Expectation-Maximization algorithm. The resulting algorithm can deal with hidden variables in Maximum Likelihood and Maximum a Posteriori estimation problems, Instrumental Variables, Regularized Optimization and Constrained Optimization problems. The advantage of the proposed algorithm is to provide a systematic procedure to build surrogate functions for a class of problems where hidden variables are usually involved. Numerical examples show the benefits of the proposed approach.
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