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Alkaline phosphatase-positive B cell lymphomas.

M Abe¹, Y Nozawa, E Wachi

¹Department of Pathology, Fukushima Medical College, Japan.

European Journal of Haematology

|September 1, 1988

Summary

Alkaline phosphatase (ALP) activity was detected in certain non-Hodgkin

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Area of Science:

Hematology
Immunology
Oncology

Background:

Non-Hodgkin's lymphomas (NHL) are a heterogeneous group of lymphoid malignancies.
Alkaline phosphatase (ALP) is an enzyme with a known role in various cellular processes.
The expression of ALP in B-cell lymphomas has not been extensively characterized.

Purpose of the Study:

To investigate the presence and significance of Alkaline phosphatase (ALP) activity in different subtypes of B-cell non-Hodgkin's lymphomas.
To determine if ALP expression correlates with specific immunophenotypes in these lymphomas.

Main Methods:

Analysis of ALP activity in 70 cases of B-cell non-Hodgkin's lymphomas.
Immunophenotypic characterization of ALP-positive neoplastic cells.
Correlation of ALP expression with lymphoma subtypes and B-cell lineage markers.

Main Results:

Alkaline phosphatase (ALP) activity was identified in specific B-cell lymphoma subtypes, including follicular, small cleaved cell; diffuse, small cleaved cell; and mantle zone lymphoma.
ALP-positive neoplastic cells exhibited an immunophenotype consistent with mantle zone (MZ) B lymphocytes.
Other B-cell lymphoma subtypes, such as diffuse large B-cell lymphoma and small noncleaved cell lymphoma, were negative for ALP.

Conclusions:

Alkaline phosphatase (ALP) expression is a feature of certain B-cell lymphomas, particularly those resembling mantle zone (MZ) B lymphocytes.
The findings suggest that ALP-positive lymphomas may represent neoplastic counterparts of normal ALP-expressing MZ B cells.
ALP activity could serve as a potential diagnostic or prognostic marker in specific B-cell lymphoma subtypes.

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