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Related Experiment Videos

Nutrition and the immune response.

B E Sheffy, R D Schultz

    The Cornell Veterinarian
    |January 1, 1978
    PubMed
    Summary

    Vitamin E and selenium deficiency severely impaired dogs' immune cell function and antibody production. Supplementation with vitamin E restored lymphocyte responsiveness, indicating its crucial role in canine immunity.

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    Area of Science:

    • Immunology
    • Nutritional Science
    • Canine Health

    Background:

    • Vitamin E and selenium are essential antioxidants.
    • Deficiencies can impact immune function.
    • Lymphocyte responsiveness is a key indicator of immune health.

    Purpose of the Study:

    • To investigate the effects of vitamin E--selenium deficiency on canine lymphocyte function.
    • To identify factors contributing to suppressed immune response.
    • To determine the efficacy of vitamin E supplementation in restoring immune function.

    Main Methods:

    • Inducing vitamin E--selenium deficiency in dogs.
    • Assessing lymphocyte responsiveness to mitogen stimulation.
    • Measuring neutralizing antibody synthesis.
    • Isolating and partially purifying a serum suppressor factor.
    • Evaluating the effects of in vivo and in vitro vitamin E supplementation.

    Main Results:

    • Complete suppression of lymphocyte responsiveness to mitogens in deficient dogs.
    • Depressed neutralizing antibody synthesis.
    • Isolation of a serum factor inhibiting lymphocyte response.
    • Restoration of lymphocyte responsiveness following vitamin E supplementation.

    Conclusions:

    • Vitamin E--selenium deficiency significantly compromises canine immune function.
    • A serum suppressor factor is involved in this immune suppression.
    • Vitamin E supplementation can reverse the negative effects of deficiency on lymphocyte function.

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