Related Experiment Video
Updated: Feb 1, 2026

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
Published on: April 23, 2017
Regiochemistry of Thiolate for Selenolate Ligand Exchange on Gold Clusters
Christopher A Hosier1, Christopher J Ackerson1
1Department of Chemistry , Colorado State University , Fort Collins , Colorado 80523 , United States.
Abstract:
Ligand exchange is a fundamental reaction of metal nanoparticles. Multiple symmetry and kinetic exchange environments are observed for thiolate protected gold nanoparticles, but the correlation between these is unclear. Structural study of ligand exchange on chalcogenide passivated gold clusters has so-far revealed the locations of 10% or fewer of incoming ligands. In a set of 13 crystal structures, we reveal the locations of up to 17 ligands of the 18 ligands in thiolate for selenolate exchanged Au25(SeR)18- x(SR) x clusters. Overall, we see a distinct preference for the locations of thiolate and selenolate ligands that emerges over time. This most-comprehensive to-date structural study of ligand exchange on gold clusters evidences a structural basis for exchange of solvated ligands, exchange of ligands between clusters, and a net reaction that amounts to translation of ligands on the cluster surface.
More Related Videos
08:21A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions
Published on: February 5, 2016
04:51Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
Published on: June 23, 2023
Related Concept Videos
E2 Reaction: Stereochemistry and Regiochemistry
When a substrate with two different β hydrogens undergoes an E2 elimination, the presence of a strong base can yield two regioisomeric alkenes. The more-substituted alkene is the major...
E1 Reaction: Stereochemistry and Regiochemistry
Ligand Binding Sites
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Ligand Binding and Linkage
Social Exchange Theory