Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Collagen autoimmunity and arthritis.

J M Stuart¹, W C Watson, A H Kang

¹Department of Medicine, University of Tennessee, Memphis.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology

|November 1, 1988

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Case-control study for risk factors for Q Fever in southwest England and Northern Ireland.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2017

Same author

Cryptosporidium outbreak linked to interactive water feature, UK: importance of guidelines.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2017

Same author

TNF-α modulates genome-wide redistribution of ΔNp63α/TAp73 and NF-κB cREL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer.

Oncogene·2016

Same author

Computational Identification of Tumor Anatomic Location Associated with Survival in 2 Large Cohorts of Human Primary Glioblastomas.

AJNR. American journal of neuroradiology·2016

Same author

Chemoprophylaxis and vaccination in preventing subsequent cases of meningococcal disease in household contacts of a case of meningococcal disease: a systematic review.

Epidemiology and infection·2015

Same author

Timeliness of epidemiological outbreak investigations in peer-reviewed European publications, January 2003 to August 2013.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2015

Collagen-induced arthritis in animals serves as a valuable model for human rheumatoid arthritis. This autoimmune condition involves joint destruction mediated by antibodies and complement activation, offering insights into disease pathogenesis.

Area of Science:

Immunology
Rheumatology
Animal Models

Background:

Collagen-induced arthritis (CIA) in animals closely mimics human rheumatoid arthritis (RA).
CIA is triggered by immunization with type II collagen, with susceptibility linked to major histocompatibility genes.
Autoimmunity to cartilage components is implicated in some human arthritis cases.

Purpose of the Study:

To investigate the pathogenesis of autoimmune-mediated joint destruction in CIA.
To explore the role of antibodies and complement in CIA development.
To utilize CIA as a model for understanding human rheumatoid arthritis.

Main Methods:

Induction of arthritis in susceptible animals via type II collagen immunization.
Analysis of antibody deposition on articular cartilage.

Related Experiment Videos

Assessment of complement involvement and IgG isotype activity.

Investigation of epitope specificity of arthritogenic antibodies.

Main Results:

Initial lesions involve antibody deposition on articular cartilage preceding overt arthritis.
Disease transfer is possible with specific antibodies into complement-sufficient recipients.
High levels of complement-binding IgG isotypes correlate with disease presence.
Rapid inflammation leads to cartilage destruction and bone erosion.

Conclusions:

CIA is a valuable animal model for studying rheumatoid arthritis pathogenesis.
Antibody-mediated immune responses and complement activation are critical in CIA.
Understanding CIA mechanisms provides insights into human autoimmune joint diseases.