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Updated: Feb 1, 2026

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment
Published on: May 10, 2022
Sudden cardiac death: Beware of hasty diagnosis!
Charles Guenancia1,2, Romaric Loffroy3,4, Frederic Chagué1
1Cardiology Department, University Hospital, Dijon, France.
Insights
A young athlete survived sudden cardiac death (SCD) due to a rare combination of hypertrophic cardiomyopathy (HCM) and an abnormal coronary artery origin. This case highlights the importance of considering dual pathologies after exercise-induced SCD in athletes.
Area of Science:
- Cardiology
- Sports Medicine
- Genetics
Background:
- Sudden cardiac death (SCD) in young athletes is a critical concern.
- Hypertrophic cardiomyopathy (HCM) and coronary artery anomalies are leading causes of exercise-induced SCD.
- The simultaneous occurrence of HCM and coronary artery anomalies is exceptionally rare.
Purpose of the Study:
- To report a unique case of SCD in a young athlete.
- To investigate the association between HCM and anomalous coronary artery origin.
- To emphasize diagnostic and management considerations for exercise-induced SCD.
Main Methods:
- Comprehensive cardiac imaging techniques were employed for diagnosis.
- Clinical management followed international guidelines for SCD.
- The patient received an implantable cardioverter-defibrillator.
Main Results:
- A 21-year-old male experienced SCD during football, successfully resuscitated.
- Diagnosis revealed coexisting HCM and an abnormal left coronary artery originating from the right coronary artery.
- Surgical correction of the coronary anomaly was not feasible due to anatomical factors.
Conclusions:
- The association of HCM and coronary artery anomalies, though uncommon, can precipitate exercise-induced SCD in young athletes.
- Thorough investigation for multiple underlying pathologies is crucial after resuscitation from exercise-induced SCD.
- Patient adherence to medical advice is a significant factor in managing high-risk individuals.
Abstract:
We report the case of a 21-year-old man admitted to the intensive-care unit after resuscitation from a sudden cardiac death (SCD) while he was playing football. Using a wide range of imaging techniques, we diagnosed a singular association between a hypertrophic cardiomyopathy (HCM) and an abnormal left coronary artery origin from the right coronary artery. Coronary artery anomalies, after HCM, are the second most common cause of SCD during exercise in young athletes, but the association between these 2 diseases is very uncommon. Following international guidelines, the patient received an implantable cardioverter-defibrillator; the coronary abnormal origin was not corrected by surgical bypass given the pre pulmonary pathway. However, this young athlete has decided to practice football again despite being advised against it. After resuscitation of an exercise-induced SCD, the possibility of an association between two pathologies should be carefully taken into account. <Learning objective: Coronary artery anomalies, after hypertrophic cardiomyopathy, are the second most common cause of sudden cardiac death during exercise in young athletes, but the association of both diseases is very uncommon. In this case, either of the two diseases could have triggered the sudden cardiac arrest. The use of a wide range of cardiac imaging techniques guided the clinical management. After resuscitation of an exercise-induced sudden cardiac arrest, the possibility of an association between two pathologies should be carefully taken into account.>.
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