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Updated: Feb 1, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
21-Year-old male with severe coronary atherosclerosis
Sajid Muneer Mirza1, Nairmeen Awad Haller1,2, Adam Dalia1
1Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Insights
Premature coronary heart disease (CHD) can affect young adults, presenting uniquely with risk factors like hypertension and smoking. Early risk factor reduction is crucial for preventing ischemic heart disease in younger populations.
Area of Science:
- Cardiology
- Preventive Medicine
Background:
- Coronary heart disease (CHD) typically affects older individuals but can occur prematurely in younger populations.
- Premature CHD in young individuals presents with distinct lipid profiles, risk factors, and clinical manifestations.
- Early onset of cardiovascular disease necessitates understanding unique risk profiles in adolescents and young adults.
Purpose of the Study:
- To present a case report of a 21-year-old male with stable angina and multivessel coronary disease.
- To highlight the distinct characteristics and risk factors associated with premature CHD in a young patient.
- To emphasize the importance of early risk factor reduction in preventing ischemic heart disease.
Main Methods:
- A comprehensive cardiac workup was performed on a 21-year-old male presenting with stable angina.
- Patient's medical history, including lipid profile, blood pressure, smoking status, obesity, and family history, was evaluated.
- Diagnostic procedures were conducted to assess the extent of coronary artery disease.
Main Results:
- The patient was diagnosed with multivessel coronary heart disease at 21 years of age.
- Identified risk factors included mild dyslipidemia, hypertension, cigarette smoking, obesity, and a family history of heart disease.
- The patient underwent coronary artery bypass surgery at a young age.
Conclusions:
- Coronary heart disease can manifest in young individuals, even at 21 years old.
- Traditional CHD risk factors are sufficient to induce ischemic heart disease in the younger population.
- Risk factor reduction strategies should be implemented early in life to mitigate the prevalence of premature CHD.
Abstract:
Coronary heart disease (CHD) is not limited to middle-aged and elderly individuals; when premature CHD develops in the younger population, it has distinct characteristics in terms of lipid profile, risk factors, and clinical presentation. The following describes a 21-year-old male who presented with stable angina, underwent a full cardiac workup, and was ultimately found to have multivessel CHD. In summary, the presence of mild dyslipidemia, high blood pressure, cigarette smoking, obesity, and a family history was sufficient to induce ischemic heart disease at such a young age.
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