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NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients

Alassane Thiam1, Sabrina Baaklini2, Babacar Mbengue3

  • 1Unité d'Immunogénétique, Institut Pasteur de Dakar, Dakar, Senegal.

Peerj
|December 12, 2018
PubMed
Abstract

Insights

Genetic variation in NCR3 (rs2736191) is linked to mild malaria but not severe malaria outcomes. Thrombocytopenia and high leukocyte counts are associated with severe malaria phenotypes.

Area of Science:

  • Genetics
  • Immunology
  • Infectious Diseases

Background:

  • Host genetic factors influence Plasmodium falciparum infection outcomes.
  • Previous studies mapped mild malaria resistance genes to chromosome 6p21.
  • NCR3-412 polymorphism (rs2736191) within this region was associated with mild malaria.

Purpose of the Study:

  • To investigate the association of NCR3-412 polymorphism with severe malaria phenotypes.
  • To assess the role of host genetic variation in malaria severity.

Main Methods:

  • Sequencing of NCR3-412 (rs2736191) in 188 malaria patients.
  • Measurement of haematological parameters.
  • Association analysis with clinical phenotypes (mild, cerebral, severe non-cerebral malaria).

Main Results:

  • Thrombocytopenia associated with cerebral and severe non-cerebral malaria.
  • High leukocyte count associated with cerebral malaria.
  • No association found between NCR3-412 and cerebral, severe non-cerebral, or overall severe malaria.

Conclusions:

  • NCR3 genetic variation likely has minimal impact on severe malaria occurrence.
  • NCR3 variation is strongly associated with mild malaria, not severe forms.
  • Thrombocytopenia and high leukocyte count are confirmed markers of severe malaria.
Keywords:
Genetic associationHost factorsMild malariaPlasmodium falciparumSevere malaria

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