Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

3.4K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.4K
Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

1.6K
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
1.6K
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

347
Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
347
Inflammation01:38

Inflammation

62.1K
Overview
62.1K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.6K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.6K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

1.1K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term efficacy of neural circuit blockade for treating blepharospasm: a retrospective case series study.

Frontiers in neurology·2026
Same author

The Importance of Kidney Health in Spina Bifida-Separating Wheat From Chaff.

JAMA network open·2026
Same author

Reply to Editorial Comment on "The Relationship between Burnout, Perfectionism, and Grit in Urology".

Urology·2026
Same author

Establishing a clinician-prioritized pediatric urology clinical research agenda in the United States.

Journal of pediatric urology·2026
Same author

Engagement of Urology Faculty With the Social Media Accounts of Residency Applicants: Does #UroSoMe Influence the Match?

Cureus·2026
Same author

The role of biopsychosocial factors in classifying pain intensity across various chronic pain conditions.

Scientific reports·2026

Related Experiment Video

Updated: Feb 1, 2026

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
08:53

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

6.8K

Diabetic bladder dysfunction is associated with bladder inflammation triggered through hyperglycemia, not polyuria.

Brian M Inouye1, Francis M Hughes1,2, Huixia Jin1

  • 1Department of Surgery, Division of Urology, Duke University Medical Center, Durham, NC, USA, monty.hughes@duke.edu.

Research and Reports in Urology
|December 12, 2018
PubMed
Summary
This summary is machine-generated.

Diabetic bladder dysfunction (DBD) involves bladder inflammation. This inflammation is caused by high blood sugar (hyperglycemia), not increased urination (polyuria), in diabetic mice.

Keywords:
cystitisdiabetesimmunityinflammationinnateurinary bladderurodynamics

More Related Videos

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

18.4K
Mouse Bladder Wall Injection
03:48

Mouse Bladder Wall Injection

Published on: July 12, 2011

24.8K

Related Experiment Videos

Last Updated: Feb 1, 2026

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
08:53

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

6.8K
Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

18.4K
Mouse Bladder Wall Injection
03:48

Mouse Bladder Wall Injection

Published on: July 12, 2011

24.8K

Area of Science:

  • Urology
  • Endocrinology
  • Nephrology

Background:

  • Diabetes mellitus is a progressive condition with severe complications.
  • Diabetic bladder dysfunction (DBD) is a common complication lacking specific treatments.
  • The bladder faces unique challenges from hyperglycemia and polyuria in diabetes.

Purpose of the Study:

  • To assess inflammation in the bladder during diabetic bladder dysfunction.
  • To determine if polyuria or hyperglycemia contributes to bladder inflammation in diabetes.

Main Methods:

  • Cystometry was performed on wild-type and diabetic (Akita) mice.
  • Diabetic mice received phlorizin, a glucose reabsorption inhibitor.
  • Serum glucose, voiding patterns, and bladder inflammation were evaluated.

Main Results:

  • Diabetic mice exhibited cystometrically-defined DBD by 15 weeks.
  • Phlorizin normalized serum glucose but increased urine output.
  • Bladder inflammation was detected in diabetic mice, but not in phlorizin-treated mice.

Conclusions:

  • Bladder inflammation correlates with DBD in diabetic mice.
  • Hyperglycemia, not polyuria, triggers bladder inflammation in this model.
  • Findings suggest targeting hyperglycemia may be key for treating DBD.