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lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

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Long non coding RNAs and ALS: Still much to do.

Stella Gagliardi¹, Cecilia Pandini^1,2, Maria Garofalo^1,2

¹Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy.

Non-Coding RNA Research

|December 12, 2018

Summary

Long non-coding RNAs (lncRNAs) are increasingly implicated in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. This review consolidates current knowledge on lncRNAs and ALS, highlighting their potential roles in disease mechanisms.

Keywords:

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Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

RNA metabolism alterations are significant in Amyotrophic Lateral Sclerosis (ALS) pathogenesis.
A limited number of long non-coding RNAs (lncRNAs) have been linked to ALS, indicating a gap in understanding their specific roles.
lncRNAs represent a promising area for exploring novel pathogenic mechanisms in ALS.

Purpose of the Study:

To review and consolidate existing data on long non-coding RNAs (lncRNAs) in the context of Amyotrophic Lateral Sclerosis (ALS).
To provide an overview of lncRNAs associated with ALS.
To explore the potential roles of lncRNAs in ALS disease mechanisms.

Main Methods:

Literature review and data synthesis.
Comprehensive search for studies investigating lncRNAs and ALS.
Compilation and analysis of reported findings on lncRNAs in ALS.

Main Results:

The current literature identifies a small but growing number of lncRNAs associated with ALS.
lncRNAs are involved in various cellular processes relevant to neurodegeneration.
Further research is needed to fully elucidate the specific functions and implications of these lncRNAs in ALS.

Conclusions:

lncRNAs are emerging as critical players in Amyotrophic Lateral Sclerosis (ALS) pathogenesis.
Understanding the role of lncRNAs in RNA metabolism may reveal new therapeutic targets for ALS.
This review underscores the need for continued investigation into lncRNAs for advancing ALS research.