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Updated: Feb 1, 2026
Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
Alemtuzumab induced ST-segment elevation and acute myocardial dysfunction
Shirin Attarian1, Cindy Y Wang1, Jorge Romero2
1Department of Internal Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Alemtuzumab can cause acute myocardial dysfunction and ECG changes after a test dose. Physicians should exercise caution and perform cardiac evaluations before administering alemtuzumab due to this serious side effect.
Area of Science:
- Cardiology
- Oncology
- Pharmacology
Background:
- Cardiac toxicity is a known side effect of chemotherapy.
- Alemtuzumab, a monoclonal antibody, has been linked to cardiac issues like heart failure and arrhythmias.
Observation:
- A 66-year-old man with small lymphocytic lymphoma developed nausea, vomiting, rigors, and tachycardia 20 minutes after an alemtuzumab test dose.
- ECG revealed ST-segment elevations, and echocardiography showed akinesis and reduced ejection fraction, indicating acute myocardial dysfunction.
Findings:
- The patient experienced ST-segment elevations and acute myocardial dysfunction following a test dose of alemtuzumab.
- Despite resolution of ECG changes, echocardiography showed persistent impairment in cardiac function 10 days later.
Implications:
- Alemtuzumab administration necessitates thorough cardiac evaluation and heightened vigilance.
- Cytokine release syndrome is a potential mechanism, suggesting possible mitigation with anti-cytokine therapies.
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