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Effect of Vitamin E in Prevention of Intraventricular Hemorrhage in Preterm Neonates

Behzad Barekatain1, Samira Saraeian2, Maryam Farghadani3

  • 1Department of Pediatrics, Division of Neonatology, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

International Journal of Preventive Medicine
|December 12, 2018
PubMed

Insights

Vitamin E supplementation did not significantly reduce the incidence of intraventricular hemorrhage (IVH) in preterm neonates. Further research with larger sample sizes is recommended to confirm these findings for neonatal brain hemorrhage prevention.

Area of Science:

  • Neonatal Medicine
  • Pediatric Neurology
  • Clinical Pharmacology

Background:

  • Intraventricular hemorrhage (IVH) is a common and severe complication in preterm neonates.
  • Current treatments for neonatal IVH are limited, emphasizing the need for preventative strategies.
  • Previous studies on Vitamin E for IVH prevention have yielded conflicting results.

Purpose of the Study:

  • To evaluate the efficacy of Vitamin E in reducing the incidence and severity of IVH in preterm neonates.
  • To investigate the potential of Vitamin E as a preventative measure against neonatal brain hemorrhage.

Main Methods:

  • A randomized clinical trial involving 76 neonates with gestational age ≤30 weeks.
  • Participants were divided into two groups: one receiving Vitamin E (10 units for 3 days) and the other receiving a placebo.
  • Brain sonography was performed on the 4th and 7th days postpartum to assess IVH incidence and severity.

Main Results:

  • The incidence of IVH on day 4 was 26.3% in the Vitamin E group versus 42.1% in the placebo group (P=0.3), showing no significant difference.
  • On day 7, IVH incidence was 17.1% in the Vitamin E group and 36.8% in the control group.
  • No statistically significant reduction in IVH was observed with Vitamin E supplementation.

Conclusions:

  • Vitamin E administration did not significantly decrease the incidence of IVH in preterm neonates within this study.
  • Larger-scale studies are necessary to definitively determine the role of Vitamin E in preventing neonatal intraventricular hemorrhage.
  • The findings suggest current Vitamin E protocols may not be effective for IVH prevention in this population.
Abstract

Keywords:
Intraventricular hemorrhageVitamin Epreterm

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