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Related Concept Videos

Autophagy01:27

Autophagy

5.9K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancer Therapies02:49

Cancer Therapies

10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Related Experiment Video

Updated: Feb 1, 2026

Orthotopic Mouse Model of Colorectal Cancer
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Orthotopic Mouse Model of Colorectal Cancer

Published on: December 4, 2007

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Autophagy and Neovascularization in Colorectal Cancer.

C D Uscatu1,2, T Dumitrescu3,4, I C Deliu5

  • 1Department of Cellular and Molecular Biology, University of Medicine and Pharmacy of Craiova.

Current Health Sciences Journal
|December 12, 2018
PubMed
Summary
This summary is machine-generated.

Autophagy is present in colorectal cancer. New blood vessel growth (neovascularization) is significantly higher in the tumor mass compared to its base, indicating altered tumor microenvironment.

Keywords:
CD105CD31CD34autophagycolorectal cancer

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Area of Science:

  • Oncology
  • Pathology
  • Vascular Biology

Background:

  • Colorectal adenocarcinoma exhibits complex microenvironmental factors influencing tumor progression.
  • Neovascularization and autophagy are critical cellular processes implicated in cancer development and growth.

Observation:

  • Autophagy puncta, indicative of the autophagy process, were consistently observed in colorectal cancer cells.
  • Immunohistochemistry using LC3, CD34, CD31, and CD105 antibodies was performed on 38 colorectal adenocarcinoma samples.

Findings:

  • Microvessel density, specifically neovascularization marked by CD105, was significantly higher within the tumor mass compared to the tumor base (p<0.0001).
  • Autophagy was present in all examined tumor regions, both at the base and within the mass.

Implications:

  • Increased neovascularization in the tumor mass suggests enhanced nutrient supply and potential for metastasis.
  • The co-occurrence of autophagy and elevated microvessel density warrants further investigation into their synergistic roles in colorectal cancer progression.