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Updated: Feb 1, 2026

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
Published on: July 16, 2018
A dual signal amplification nanosensor based on SERS technology for detection of tumor-related DNA
Duo Lin1, Tianxun Gong, Sufang Qiu
1College of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
Abstract:
A dual signal amplification method based on surface-enhanced Raman scattering (SERS) is developed by photo-triggered release of SERS probes from mesoporous silica-coated Au nanorods (SiO2@Au) and the use of a specially-designed SERS substrate with an internal reference. Two metal carbonyl (metal-CO) labels (Os-SCO and Re-SCO) are proposed here as novel interference-free labels. Results demonstrate that tumor-related DNA can be quantitatively detected by this reliable and ultra-sensitive SERS platform.
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