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A smart tumor microenvironment responsive nanoplatform based on upconversion nanoparticles for efficient multimodal

Shikai Liu1, Wenting Li, Shili Gai

  • 1Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China. gaishili@hrbeu.edu.cn hefei@hrbeu.edu.cn yangpiaoping@hrbeu.edu.cn.

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This study introduces a novel nanoplatform for cancer therapy using near-infrared light. The platform combines dual-mode imaging and drug delivery for targeted, responsive tumor treatment.

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Near-infrared (NIR) light-induced imaging-guided cancer therapy is an emerging field.
  • Developing effective theranostic nanoplatforms is crucial for precise cancer treatment.

Purpose of the Study:

  • To develop a novel theranostic nanoplatform for imaging-guided cancer therapy.
  • To achieve dual-mode imaging (upconversion luminescence and CT) and synergistic therapy.

Main Methods:

  • Synthesized a nanoplatform by modifying polyoxometalate nanoclusters onto mesoporous silica-coated upconversion nanoparticles (UCNPs).
  • Loaded doxorubicin (DOX) and coated with a folate-chitosan shell for tumor targeting.
  • Investigated NIR light-induced upconversion luminescence (UCL), CT imaging, and synergistic chemo-photothermal therapy.

Main Results:

  • The nanoplatform exhibited dual-mode imaging capabilities (UCL and CT) upon 808 nm NIR light irradiation.
  • Demonstrated efficient synergistic therapy through combined chemotherapy (DOX release) and photothermal effect.
  • Showcased tumor microenvironment (TME) responsiveness, with targeted delivery and triggered drug release.

Conclusions:

  • The developed nanoplatform is a promising tool for imaging-guided cancer therapy.
  • Its TME-responsive properties and synergistic therapeutic effects offer significant potential for advanced cancer treatment.