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Updated: Feb 1, 2026

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
Published on: March 1, 2022
A diagnostic algorithm for pulmonary hypertension due to left heart disease in resource-limited settings: can busy
Anastase Dzudie1, Andre Pascal Kengne2, Kim Lamont3
1Department of Internal Medicine and Department of Physiology, Faculty of Medicine, University of Yaoundé, Yaoundé, Cameroon; and Soweto Cardiovascular Research Unit, University of the Witwatersrand, Johannesburg, South Africa; Clinical Research Education Networking and Consultancy, and Cardiology Unit, Douala General Hospital, Douala, Cameroon; NIH Millennium Fogarty Chronic Disease Leadership Program, Stanford, USA.
Abstract:
Pulmonary hypertension (PH) has progressively moved from an orphan disease to a significant global health problem with a major disease burden in limited7hyphen;resource countries, where over 97% of patients live. The aetiologies of PH differ between high- and low-income nations, but PH due to left heart disease is credited to be the most frequent contemporary form. Although a straightforward diagnosis of PH requires the use of right heart catheterisation (RHC), access to equipment for RHC is a deterrent. Furthermore, the risk associated with RHC limits its uptake to a selection of specialised centres. Moreover, the rigour and clinical reasoning for diagnosis in clinical medicine is rapidly changing and revealing that PH can complicate a diverse range of medical conditions needing other explorations. In this article, we provide for the busy clinician, a simplified diagnostic algorithm for PH that is relevant for making a correct early diagnosis and limiting the impact of PH.
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