Related Experiment Video
Updated: Feb 1, 2026
07:17
A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
Published on: January 29, 2021
6.4K
Tumor-Directed Therapeutic Targets in Cushing Disease
Marily Theodoropoulou1, Martin Reincke1
1Medizinische Klinik und Poliklinik IV, Ludwig Maximilian University Munich, Munich, Germany.
The Journal of Clinical Endocrinology and Metabolism
|December 12, 2018
Summary
Effective tumor-targeted therapies for Cushing disease (CD), a rare cause of hypercortisolism, are limited. Further research is crucial to establish novel therapeutic options for this severe condition.
Area of Science:
- Endocrinology
- Oncology
- Pharmacology
Background:
- Cushing disease (CD) is the most common cause of endogenous hypercortisolism.
- CD leads to severe comorbidities and high mortality.
- Current tumor-targeted therapies for CD are limited.
Purpose of the Study:
- To review current and potential tumor-targeted pharmacological therapies for Cushing disease.
- To highlight the unmet need for effective treatments in CD.
Main Methods:
- Literature search of PubMed using keywords: "corticotroph", "Cushing's disease", and therapeutic agents.
- Review of associated references from retrieved papers.
- Exploration of ClinicalTrials.gov for "Cushing disease" to identify potential therapeutics.
Main Results:
- Current therapies include dopamine agonists (cabergoline) and somatostatin analogs (pasireotide), with variable efficacy, response escape, and side effects.
- Preclinical studies suggest potential agents like retinoic acid, silibinin, and roscovitine for corticotroph pathophysiology.
- The efficacy and safety of these potential drugs require further determination.
Conclusions:
- There is a significant lack of effective tumor-targeted pharmacological therapy for many Cushing disease patients.
- Coordinated research efforts are essential to establish the efficacy and safety of novel therapeutics for CD.
More Related Videos
Related Concept Videos
01:11Direct-Acting Cholinergic Agonists: Therapeutic Uses
1.7K
Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
1.7K
01:13Therapeutic Index
6.8K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.8K
01:09Directing Effect of Substituents: meta-Directing Groups
6.0K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
01:30Therapeutic Communication
8.1K
Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
8.1K
01:26Cholinergic Antagonists: Therapeutic Uses
1.5K
Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
1.5K
01:29Microorganisms in Medicine and Therapeutics
1.1K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.1K