Related Experiment Video
Updated: Feb 1, 2026

Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects
Published on: February 18, 2014
Interactive Effects of Mixtures of Phototoxic PAHs
1Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Abstract:
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components in complex mixtures derived from petroleum based products. PAHs are unique in their ability to absorb UV light, resulting in significant increases in acute toxicity. The objective of this study was to determine if mixtures of the phototoxic PAHs fluoranthene, pyrene, and anthracene conform to the additive model of toxicity. Median lethal concentrations (LC50) were calculated for mysid shrimp (Americamysis bahia) and inland silverside (Menidia beryllina) exposed to individual, binary, and ternary mixtures of the selected PAHs. Mixtures were evaluated on a toxic unit basis to account for potency differences and toxicity data was analyzed using the concentration-addition and independent-action models. Data indicated that the model of additivity is sufficient in describing the toxicity of mixtures of phototoxic PAHs; therefore predictive models should consider an additivity model for assessing the toxicity of hydrocarbon mixtures.
More Related Videos
Related Concept Videos
Mixtures of Acids
A Mixture of a Strong Acid and a Weak Acid
In a mixture of a strong acid and a weak acid, the strong acid dissociates completely and becomes a source of almost all the hydronium ions...
Mixtures of Acids
In a strong and weak acid mixture, the strong acid dissociates completely and becomes a source of almost all the hydronium ions present in the solution. In contrast, the weak acid shows...
Racemic Mixtures and the Resolution of Enantiomers
Mixtures of Gases: Dalton's Law of Partial Pressures and Mole Fractions
Buffer Effectiveness
The buffer capacity is the amount of acid or base that can be added to a given volume...
Predator-Prey Interactions

