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Examining BCL-2 Family Function with Large Unilamellar Vesicles
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Published on: October 5, 2012

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Database and Bioinformatic Analysis of BCL-2 Family Proteins and BH3-Only Proteins

Abdel Aouacheria1, Vincent Navratil2, Christophe Combet3

  • 1ISEM, Institut des Sciences de l'Evolution de Montpellier, Université de Montpellier, UMR 5554, CNRS, IRD, EPHE, Montpellier, France. abdel.aouacheria@umontpellier.fr.

Methods in Molecular Biology (Clifton, N.J.)
|December 12, 2018
PubMed

Insights

Investigate BCL-2 homologs and BH3-only proteins using computational resources like BCL2DB. This helps analyze cell death regulators crucial for animal cell life and death, with therapeutic potential in cancer.

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Cell Death Regulation

Background:

  • The BCL-2 protein family comprises diverse regulators critical for animal cell apoptosis.
  • Dysregulation of BCL-2 proteins is implicated in human diseases, notably cancer, making them therapeutic targets.
  • The omics era necessitates efficient computational tools for analyzing cell death pathway components.

Purpose of the Study:

  • To present computational resources and bioinformatics tools for investigating BCL-2 homologs and BH3-only proteins.
  • To facilitate data retrieval and analysis of molecular players in cell death pathways.
  • To support research on the BCL-2 family's role in cell survival and apoptosis.

Main Methods:

  • Utilizing the reference database BCL2DB for BCL-2 protein data.
  • Employing generic and specific bioinformatics tools for data analysis.
  • Investigating protein structure, function, and phylogenetic relationships.

Main Results:

  • Availability of the BCL2DB database for comprehensive BCL-2 protein information.
  • Demonstration of bioinformatics tools for analyzing BCL-2 homologs and BH3-only proteins.
  • Facilitation of efficient data retrieval and analysis in cell death research.

Conclusions:

  • Computational resources like BCL2DB are essential for studying the BCL-2 protein family.
  • Bioinformatics tools enhance the investigation of cell death regulators.
  • These resources aid in understanding protein roles and identifying therapeutic targets in diseases like cancer.
Keywords:
ApoptosisBCL-2BH3BioinformaticsCell deathDatabasesOmicsProtein domainsProtein motifsStructure–function relationships

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