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Updated: Feb 1, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
Inflammasomes in Clinical Practice: A Brief Introduction
Elísabet Alcocer-Gómez1, Beatriz Castejón-Vega2,3, Macarena López-Sánchez3,4
1Departamento de Psicología Experimental, Facultad de Psicología, Universidad de Sevilla, Sevilla, Spain. agelisabet@gmail.com.
Abstract:
Inflammasomes are multiprotein complexes formed and activated after exposure to pathogenic microbes and host danger signals that control the maturation and production of IL-1β and IL-18. Their implication in different diseases such as cardiovascular, neurodegenerative, psychiatric, and metabolic diseases opens a door to developing new therapeutic perspectives. However, the rapid increase in the knowledge about inflammasomes is associated with their involvement in clinical practice. Two topics open the way to future lines of research: a clinical trial with the new specific inhibitors and the development of diagnostic tools.
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