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Related Concept Videos

Kidney Structure01:45

Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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External Anatomy of the Kidney01:21

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The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
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Internal Anatomy of the Kidney01:12

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The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
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Renal Cortex
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Anatomy of the Genitourinary System I: Kidneys and Ureters01:11

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The upper urinary system comprises two kidneys and two ureters, which are crucial in filtering blood and forming urine.KidneysLocation and Structure:The kidneys are two bean-shaped organs positioned behind the peritoneum on either side of the spine.Kidneys are between the 12th thoracic (T12) and the 3rd lumbar (L3) vertebrae.The position of the liver causes the right kidney to sit slightly lower than the left.Protective Layers:Each kidney is enveloped in a tough, fibrous membrane called the...
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Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

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Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
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The Mouse Isolated Perfused Kidney Technique
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Inflammasomes in the Kidney.

Holly L Hutton1, Maliha A Alikhan1, A Richard Kitching2,3,4

  • 1Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, Australia.

Experientia Supplementum (2012)
|December 12, 2018
PubMed
Summary
This summary is machine-generated.

Inflammasomes play a key role in various kidney diseases, with IL-1β and IL-18 being crucial therapeutic targets. Targeting inflammasomes offers future potential for treating kidney conditions.

Keywords:
Acute kidney injuryDiabetic nephropathyGlomerulonephritisInflammasomeInterleukin-1β

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Area of Science:

  • Nephrology
  • Immunology
  • Molecular Biology

Background:

  • Inflammasomes are critical in kidney diseases, involving both innate and adaptive immunity.
  • Interleukin-1 beta (IL-1β) and IL-18 are validated therapeutic targets in kidney disease.
  • Renal tissue cells, not just leukocytes, express functional inflammasome components.

Purpose of the Study:

  • To review the role of inflammasomes in kidney diseases.
  • To highlight therapeutic targets within inflammasome pathways.
  • To discuss the potential of inflammasome-targeted therapies for kidney disease.

Main Methods:

  • Literature review of studies on inflammasomes in kidney disease.
  • Analysis of research focusing on NLRP3 inflammasome and other inflammasomes.
  • Examination of endogenous substances activating inflammasomes in kidney injury.

Main Results:

  • Inflammasomes are implicated in diverse acute and chronic kidney diseases.
  • IL-1β and IL-18 are key mediators and therapeutic targets.
  • Endogenous substances activating inflammasomes contribute to kidney injury.

Conclusions:

  • Inflammasome pathways are central to kidney disease pathogenesis.
  • Targeting inflammasomes and their products presents a promising therapeutic strategy for kidney diseases.
  • Further elucidation of inflammasome mechanisms is needed for optimized treatment.