Related Experiment Video
Updated: Feb 1, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
Role of Inflammasomes in the Development of Gastrointestinal Diseases
Mazhar A Kanak1, Yoshitaro Shindo1, Pavithra SaiKumar2
1Division of Transplantation, Department of Surgery, Virginia Commonwealth University Medical Center, Richmond, VA, USA.
Abstract:
Many diseases of the gastrointestinal tract have been attributed to chronic inflammation, and a few have identified the role of inflammasomes in their pathogenesis. Inflammasomes are a group of protein complexes comprising of several intracellular proteins that link the sensing of microbial products and metabolic stress to the proteolytic activation of the proinflammatory cytokines. Recent studies have implicated activation of several families of NOD-like receptors (NLRs) which are major components of inflammasomes in the development and exacerbation of many diseases of human systems. In this chapter, we discuss the role of inflammasomes in some of the most prevalent diseases of the gastrointestinal tract and highlight potential targets for treatment.
Related Concept Videos
Anatomy of the Gastrointestinal System
Here's a detailed walkthrough of this complex system:
Gastrointestinal Motility Disorders
Histology of the Gastrointestinal (GI) Tract
The mucosa is sometimes called a mucous membrane due to its mucus-secreting features. This membrane is composed of epithelium, which directly interacts with ingested substances, and the lamina propria, a layer...
Physiology of the Gastrointestinal System I: Ingestion and Propulsion
Physiology of the Gastrointestinal System II: Digestion and Absorption
Digestion begins in the mouth, where food undergoes mechanical breakdown by chewing and combines with saliva. Salivary amylase, an enzyme in saliva, starts the breakdown of starches into maltose. The food then travels down the esophagus to the stomach.
In the stomach, a...
Physiology of the Gastrointestinal System III: Elimination

