Related Experiment Video
Updated: Feb 1, 2026
28:13
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
34.1K
Comparison of phase mapping and electrogram-based driver mapping for catheter ablation in atrial fibrillation
Chin-Yu Lin1,2,3, Yenn-Jiang Lin1,2, Sanjiv M Narayan4
1Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang-Ming University, Taipei City, Taiwan.
Pacing and Clinical Electrophysiology : PACE
|December 12, 2018
Summary
Driver-guided ablation improves atrial fibrillation (AF) outcomes. This strategy increases acute AF termination and reduces arrhythmia recurrence compared to conventional methods, with comparable safety.
Area of Science:
- Cardiology
- Medical Technology
- Electrophysiology
Background:
- Atrial fibrillation (AF) management often involves pulmonary vein isolation.
- Adjunctive driver-guided ablation is explored to enhance success rates in AF patients.
- Identifying and ablating drivers/rotors is a key focus for improving AF treatment.
Purpose of the Study:
- To evaluate mapping techniques for identifying AF drivers/rotors.
- To assess the benefits of driver/rotor-guided ablation in paroxysmal and persistent AF (PerAF).
Main Methods:
- Systematic search of PubMed for controlled trials on driver-guided ablation for AF.
- Inclusion of studies reporting efficacy and safety outcomes.
- Subgroup analyses comparing driver mapping methods in PerAF, using odds ratios (ORs).
Main Results:
- Seven studies met inclusion criteria (2 RCTs, 1 quasiexperimental, 4 observational).
- Driver-guided ablation showed higher acute AF termination rates (OR: 4.62) and lower arrhythmia recurrence (OR: 0.44).
- Complication incidence was comparable to conventional strategies.
Conclusions:
- Adjunctive driver-guided catheter ablation increases freedom from AF/atrial tachycardia (AT) versus conventional methods.
- Phase mapping may be superior to electrogram-based driver mapping for PerAF ablation.
Related Concept Videos
01:42Microtubule Associated Proteins (MAPs)
5.9K
Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are widespread across different organisms and have conserved protein motifs, like the multi-TOG domain for tubulin binding found in the CLASP family of MAPs. Some MAPs are lineage-specific based on their conserved domains. Their functions depend upon the cytoskeletal architecture and cell type they are located within. In-plant cells, a specific...
5.9K
01:29Plotting of Topographic Maps
524
Topographic maps represent the Earth's surface features using contour lines, which connect points of equal elevation to create a two-dimensional representation of three-dimensional terrain. Creating a topographic map requires a systematic approach.Begin by plotting a scaled grid and marking intersections corresponding to the survey's elevation data points. Assign elevation values at these intersections to build the base map. Next, determine contour levels using a consistent contour interval,...
524
01:29Coordinates and Map Projections
612
Coordinates and map projections are essential tools in accurately representing the Earth's surface for various applications, ranging from navigation to spatial analysis. The latitude and longitude coordinate system is a universally recognized framework for defining locations. Latitude specifies the distance of a point north or south of the equator, measured in degrees from 0° at the equator to 90° at the poles. Longitude indicates a location's position east or west of the prime meridian,...
612
03:03Amyloid Fibrils
11.9K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
11.9K
03:03Amyloid Fibrils
6.4K
6.4K
02:39Phase Diagrams
50.2K
A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
50.2K