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The clinical impact of exosomes in cardiovascular disorders: From basic science to clinical application

Farzaneh Ghafarian1, Mehran Pashirzad2, Majid Khazaei1

  • 1Department of Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Journal of Cellular Physiology
|December 12, 2018
PubMed

Insights

Exosomes, tiny vesicles involved in cell communication, show promise as biomarkers and therapeutic targets for cardiovascular disease (CVD). Research explores their role in cardiovascular health and potential treatments for CVD.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular disease (CVD) remains a leading global cause of mortality.
  • Accurate CVD risk biomarkers and effective treatments are urgently needed.
  • Exosomes mediate intercellular communication through their diverse molecular cargo.

Purpose of the Study:

  • To review the role of exosomes in cardiovascular physiology.
  • To explore the therapeutic potential of exosomes in cardiovascular disorders.
  • To emphasize current preclinical findings on exosome-based CVD strategies.

Main Methods:

  • Literature review of preclinical studies.
  • Analysis of exosome composition and function.
  • Evaluation of exosome-based diagnostic and therapeutic strategies.

Main Results:

  • Exosomes play a significant role in cardiovascular intercellular communication.
  • Exosomes contain various biomolecules (proteins, lipids, nucleic acids) relevant to CVD.
  • Preclinical data suggest exosome-based approaches for CVD diagnosis and treatment.

Conclusions:

  • Exosomes offer promising avenues for CVD biomarker discovery.
  • Exosomes present potential as novel therapeutic agents for cardiovascular disorders.
  • Further preclinical research is essential to translate exosome potential into clinical applications.

Keywords:
biomarkercardiovascular diseasesexosomesnucleic acid contents

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