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Published on: March 29, 2018
Developmental defects of enamel in the deciduous incisors of infants born preterm: Prospective cohort
Andréa Araujo de Oliveira Cortines1, Patrícia Corrêa-Faria2, Liselotte Paulsson3
1University Hospital, Universidade Federal de Goiás, Goiânia, GO, Brazil.
Insights
Developmental defects of enamel (DDE) are common in preterm infants, especially those born extremely or very preterm. Intubation and neonatal intensive care unit admission are associated with these enamel defects.
Area of Science:
- Pediatric Dentistry
- Neonatology
- Developmental Biology
Background:
- Developmental defects of enamel (DDE) in preterm infants are not well understood.
- DDE may lead to dental caries, poor nutrition, and growth issues.
Purpose of the Study:
- To evaluate factors associated with DDE in preterm infants.
- To clarify the prevalence and risk factors for DDE in this population.
Main Methods:
- Prospective cohort study of 54 preterm infants from birth to 24 months.
- Dental examinations to identify and categorize DDE.
- Analysis of perinatal variables and correlation with DDE.
Main Results:
- 46.3% of preterm infants presented with DDE.
- Higher incidence of DDE in extremely/very preterm infants, those with very low birth weight, and those admitted to the NICU.
- Intubation was also a significant risk factor for DDE.
Conclusions:
- High incidence of incisor enamel defects in preterm infants.
- Prematurity and local trauma from intubation are linked to DDE.
- Further research is needed to understand long-term implications.
Objective:
Developmental defects of enamel (DDE) in preterm infants still require clarification and may favour dental caries, lower food intake and greater difficulty with weight-height gain. We evaluated factors associated with DDE in preterm infants.
Subjects And Methods:
In this prospective cohort study, we monitored 54 prematurely born infants from birth to 24 months of age. Trained and calibrated dentists examined the oral cavity of these children to identify and categorize DDE. Information on perinatal variables was collected from the infants' medical records and interviews with their mothers. The data were analysed using Student's t test, a chi-squared test and Pearson's product-moment correlation coefficient.
Results:
A total of 46.3% of the 54 children presented DDE, which was observed more frequently in the left hemiarch in children born extremely (<28 weeks of gestation) or very preterm (28 to <32 weeks; RR = 2.2; 95% CI 1.3-3.6), with very low birthweight (<1,500 g; RR = 2.0; 95% CI 1.1-3.5), who were admitted to the neonatal intensive care unit (RR = 1.3; 95% CI 1.0-1.7), and who were intubated (RR = 1.6; 95% CI 1.1-2.2).
Conclusions:
The high incidence of incisor enamel defects, particularly on the left side, was related to higher risk prematurity and to local trauma from intubation.
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