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Reply to Chen et al.: Parametric methods for cluster inference perform worse for two-sided t-tests
Anders Eklund1,2,3, Hans Knutsson1,3, Thomas E Nichols4,5,6
1Division of Medical Informatics, Department of Biomedical Engineering, Linköping University, Linköping, Sweden.
Abstract:
One-sided t-tests are commonly used in the neuroimaging field, but two-sided tests should be the default unless a researcher has a strong reason for using a one-sided test. Here we extend our previous work on cluster false positive rates, which used one-sided tests, to two-sided tests. Briefly, we found that parametric methods perform worse for two-sided t-tests, and that nonparametric methods perform equally well for one-sided and two-sided tests.
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