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Longitudinal clinical studies with antimicrobial mouthrinses
1Department of Oral Diagnosis, Baltimore College of Dental Surgery, Dental School, University of Maryland.
Journal of Clinical Periodontology
|September 1, 1988
Summary
Long-term clinical studies are essential for evaluating antimicrobial mouthrinses. Rigorous trials demonstrate the efficacy of agents like Listerine and chlorhexidine in reducing plaque and gingivitis.
Area of Science:
- Dental Science
- Microbiology
- Clinical Research
Background:
- Antimicrobial mouthrinses are used for plaque and gingivitis prevention and treatment.
- Evaluating their long-term effectiveness requires specific study designs.
Purpose of the Study:
- To outline criteria for robust long-term clinical studies assessing antimicrobial mouthrinses.
- To review existing evidence on mouthrinse efficacy and side effects.
Main Methods:
- Studies should be double-blind, include a control group, and last at least 6 months.
- Microbiological assessments and clinical indices should be measured at baseline, intermediate points, and 6 months.
- Monitoring for pathogenic microorganisms and side effects is crucial.
Main Results:
- Listerine and chlorhexidine have demonstrated efficacy in reducing plaque and gingivitis in published studies.
- Sanguinarine shows preliminary evidence of effectiveness.
- Common side effects include taste alteration (Listerine) and increased stain/calculus (chlorhexidine).
Conclusions:
- Long-term studies meeting specific criteria support the efficacy of certain antimicrobial mouthrinses.
- Potential side effects must be considered when recommending these agents for patient use.
- Further research may explore other agents like sanguinarine.