Related Experiment Video

Updated: Feb 1, 2026

Multimodality Diagnosis of Mesenteric Ischemia
05:07

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

1.3K

Oral Antibiotics Reduce Intestinal Necrosis in Acute Mesenteric Ischemia: A Prospective Cohort Study

Alexandre Nuzzo1,2, Leon Maggiori3,2, Catherine Paugam-Burtz4,2

  • 1APHP, Department of Gastroenterology, IBD and Intestinal Failure, Beaujon Hospital, 92110, Clichy, France.

The American Journal of Gastroenterology
|December 13, 2018
PubMed
Abstract

Insights

Oral antibiotics may prevent irreversible transmural intestinal necrosis (ITIN) in acute mesenteric ischemia (AMI). This treatment, alongside early revascularization, reduces ITIN risk by lowering bacterial load and translocation.

Area of Science:

  • Gastroenterology
  • Surgical Innovation
  • Clinical Research

Background:

  • Acute mesenteric ischemia (AMI) is a critical condition with high rates of irreversible transmural intestinal necrosis (ITIN).
  • Identifying effective preventative treatments for ITIN progression in AMI patients is crucial for improving outcomes.

Purpose of the Study:

  • To identify treatments that can prevent the progression of AMI to ITIN.
  • To evaluate the impact of various interventions on ITIN development in AMI patients.

Main Methods:

  • Prospective observational cohort study conducted at a French intestinal stroke center.
  • Multivariate analysis utilizing a time-dependent Cox regression model.
  • Inclusion of 67 patients diagnosed with AMI between 2009 and 2015.

Main Results:

  • The incidence of ITIN was 34%, with an overall mortality rate of 13%.
  • Oral antibiotics were independently associated with a significantly decreased risk of ITIN (HR: 0.16; p=0.01).

Conclusions:

  • Oral antibiotics, in conjunction with early revascularization, may reduce the progression of AMI to ITIN.
  • This protective effect is likely mediated by a decrease in luminal bacterial load and bacterial translocation.

More Related Videos

Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery06:29

Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery

Published on: October 20, 2023

2.3K
Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment08:33

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

13.9K

Related Concept Videos

Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
6.6K
Antibiotic Selection00:57

Antibiotic Selection

Overview
59.9K
Anatomy of the Intestines01:23

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
87.4K
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
404
Oral Cavity01:11

Oral Cavity

The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
3.1K
Reducing Line Loss01:18

Reducing Line Loss

In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
389