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TRIM2 downregulation in clear cell renal cell carcinoma affects cell proliferation, migration, and invasion and

Wen Xiao1, Xuegang Wang1, Tao Wang1

  • 1Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China, xmfhxjc@163.com.

Cancer Management and Research
|December 13, 2018
PubMed
Abstract

Insights

Tripartite motif containing 2 (TRIM2) acts as an antitumor gene in clear cell renal cell carcinoma (ccRCC). Lower TRIM2 expression correlates with poor prognosis, suggesting TRIM2 modulation as a potential ccRCC treatment strategy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Tripartite motif containing (TRIM) proteins are implicated in cancer pathogenesis.
  • The specific role of TRIM2 in clear cell renal cell carcinoma (ccRCC) is not well understood.

Purpose of the Study:

  • To investigate the clinical value and biological function of TRIM2 in ccRCC.
  • To determine if TRIM2 expression can serve as a prognostic indicator for ccRCC patients.

Main Methods:

  • Analysis of The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) database for TRIM2 expression.
  • Kaplan-Meier survival analysis and multivariate analysis for prognostic significance.
  • Western blotting, immunohistochemistry, and gain-of-function assays to assess TRIM2's biological role.

Main Results:

  • TRIM2 expression was significantly lower in ccRCC tissues and cell lines compared to normal controls.
  • Lower TRIM2 expression was associated with adverse clinicopathological factors and poorer prognosis (overall survival and disease-free survival).
  • Overexpression of TRIM2 suppressed proliferation, migration, and invasion in ccRCC cells.

Conclusions:

  • TRIM2 functions as an onco-suppressor in ccRCC.
  • TRIM2 is a potential prognostic biomarker for ccRCC.
  • Targeting TRIM2 may represent a novel therapeutic strategy for ccRCC.
Keywords:
TRIM2ccRCCprognostic indicatortumor suppressor

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