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Current and Emerging Therapeutic Options for Gastroparesis
Aung S Myint1, Brandon Rieders1, Mohammed Tashkandi1
1Dr Myint, Dr Rieders, and Dr Tashkandi are gastroenterology fellows in the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center and are affiliated with Medical Faculty Associates, both in Washington, DC. Dr Borum is a professor of medicine at George Washington University School of Medicine in Washington, DC; director of the Division of Gastroenterology and Liver Diseases at George Washington University Medical Center; and is affiliated with Medical Faculty Associates. Dr Koh and Dr Stephen are in private practice in Silver Spring, Maryland. Dr Doman is a clinical professor of medicine at George Washington University School of Medicine and is in private practice in Silver Spring, Maryland.
Gastroparesis, a debilitating gut disorder, requires better treatments due to limited options. Research explores new drugs like relamorelin and endoscopic procedures to improve gastric emptying and manage symptoms effectively.
Area of Science:
- Gastroenterology
- Digestive Motility Disorders
- Pharmacology
Background:
- Gastroparesis is a complex condition characterized by delayed gastric emptying.
- Current treatments for gastroparesis have limited efficacy and potential side effects.
- There is a significant need for novel therapeutic strategies.
Purpose of the Study:
- To review current and emerging therapeutic options for gastroparesis.
- To highlight promising investigational pharmacologic and endoscopic therapies.
- To emphasize the need for further research in gastroparesis treatment.
Main Methods:
- Review of existing literature on gastroparesis treatments.
- Analysis of investigational pharmacologic agents (e.g., relamorelin, prucalopride, aprepitant).
- Evaluation of novel endoscopic and surgical interventions, including gastric peroral endoscopic pyloromyotomy.
Main Results:
- Gastric peroral endoscopic pyloromyotomy shows promise in improving gastric emptying.
- Investigational drugs like relamorelin, prucalopride, and aprepitant are under evaluation.
- A comprehensive approach including dietary, pharmacologic, electrical stimulation, endoscopic, and surgical methods is considered.
Conclusions:
- Effective management of gastroparesis remains challenging.
- Emerging therapies offer new hope for patients with gastroparesis.
- Continued research is crucial to address the morbidity associated with gastroparesis.
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