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Formulation and In Vitro Evaluation of Alendronate Sodium/PLGA Microspheres for Applications in Bone Related
A G Deca1, I Belu2, O Croitoru3
1University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Doctoral School.
Current Health Sciences Journal
|December 13, 2018
Summary
Sodium alendronate (AL) was successfully encapsulated into poly (lactic-co-glycolic acid) (PLGA) microspheres. These microspheres demonstrated a sustained drug release for up to 21 days, indicating potential for bone disorder treatments.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Bisphosphonates are crucial for developing novel bone disorder therapies.
- Microencapsulation via solvent evaporation enables controlled drug release.
- Poly (lactic-co-glycolic acid) (PLGA) is a versatile biodegradable polymer for drug delivery.
Purpose of the Study:
- To encapsulate sodium alendronate (AL) into PLGA microspheres with high efficiency.
- To achieve a sustained, prolonged release of sodium alendronate from the microspheres.
- To evaluate the potential of PLGA/AL microspheres for bone disease treatment.
Main Methods:
- Microspheres were prepared using the water/oil/water solvent evaporation technique.
- Fourier Transform Infrared (FTIR) spectroscopy was employed for microsphere characterization.
- Chromatographic analysis determined encapsulation efficiency and in vitro drug release profiles.
Main Results:
- The solvent evaporation method yielded PLGA/AL microspheres with excellent entrapment efficiency.
- In vitro studies showed sustained release of sodium alendronate for up to 21 days.
- The microspheres exhibited a clear sustained-release characteristic.
Conclusions:
- PLGA/AL microspheres demonstrate a promising prolonged drug release profile.
- These microspheres are suitable for controlled release systems targeting bone diseases.
- The developed system offers a potential advancement in treating skeletal disorders.
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