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Updated: Feb 1, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Mediators of Inflammation - A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma
Mircea Tampa1,2, Madalina Irina Mitran1,2, Cristina Iulia Mitran1,2
1"Victor Babes" Clinical Hospital for Infectious Diseases, 281 Mihai Bravu, 030303 Bucharest, Romania.
Abstract:
Oral squamous cell carcinoma (OSCC) is the most common tumour of the oral cavity, associated with significant morbidity and mortality. It is a multifactorial condition, both genetic and environmental factors being involved in its development and progression. Its pathogenesis is not fully elucidated, but a pivotal role has been attributed to inflammation, strong evidence supporting the association between chronic inflammation and carcinogenesis. Moreover, an increasing number of studies have investigated the role of different mediators of inflammation in the early detection of OSCC. In this review, we have summarized the main markers of inflammation that could be useful in diagnosis and shed some light in OSCC pathogenesis.
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