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Immune Checkpoint Inhibitors-Induced Colitis.

Yun Tian1,2, Hamzah Abu-Sbeih3, Yinghong Wang4

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Advances in Experimental Medicine and Biology
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Summary

Immune checkpoint inhibitors (ICIs) benefit cancer patients but can cause immune-related adverse events (irAEs), including diarrhea and colitis. Management varies from anti-diarrheal agents to immunosuppressants based on irAE severity.

Keywords:
ColitisCorticosteroidsDiarrheaImmune checkpoint inhibitorsImmunotherapyInfliximabSteroids

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Area of Science:

  • Oncology
  • Immunology
  • Gastroenterology

Background:

  • Immune checkpoint inhibitors (ICIs) are crucial in cancer therapy.
  • Immune-related adverse events (irAEs) are common side effects.
  • Gastrointestinal irAEs, like colitis, can be severe and limit treatment.

Purpose of the Study:

  • To summarize the clinical presentation and management of ICI-induced colitis.
  • To highlight the spectrum of severity for these gastrointestinal irAEs.

Main Methods:

  • Review of clinical symptoms.
  • Physical examination findings.
  • Diagnostic tools including stool tests, endoscopy, and imaging.

Main Results:

  • ICI-induced colitis presents with varying severity, from mild to life-threatening.
  • Diagnosis relies on a combination of clinical and diagnostic evaluations.
  • Management strategies are tailored to symptom severity.

Conclusions:

  • ICI-induced colitis is a significant concern in cancer patients receiving immunotherapy.
  • Prompt diagnosis and appropriate management are essential for patient outcomes.
  • Treatment approaches range from conservative measures to potent immunosuppression.