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Updated: Feb 1, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Suicide Gene Therapy for Oral Squamous Cell Carcinoma
Henrique Faneca1, Nejat Düzgüneş2, Maria C Pedroso de Lima3
1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Abstract:
Suicide gene therapy has been tested for the treatment of a variety of cancers, including oral cancer. Among the various suicide gene therapy approaches that have been reported, the Herpes Simplex Virus thymidine kinase (HSV-tk)/ganciclovir (GCV) system is one of the most extensively studied systems, holding great promise in cancer therapy. In this chapter, we describe methods to use the HSV-tk/GCV system to achieve antitumor activity, both in cultured oral cancer cells and in orthotopic and subcutaneous murine models of oral squamous cell carcinoma, using ligand-associated lipoplexes for enhancing therapeutic delivery.
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