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Noninvasive Monitoring of Suicide Gene Therapy by Using Multimodal Molecular Imaging

Bryan Holvoet1,2, Cindy Leten2,3, Christophe M Deroose1,2

  • 1Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, University of Leuven, Leuven, Belgium.

Methods in Molecular Biology (Clifton, N.J.)
|December 13, 2018
PubMed

Insights

This study explores using suicide genes in therapeutic cells for cancer and regenerative medicine. It highlights the need for in vivo imaging to monitor cell location, viability, and suicide gene expression for safety and efficacy.

Area of Science:

  • Biomedical Engineering
  • Molecular Biology
  • Medical Imaging

Background:

  • Suicide gene therapy offers potential for treating tumors and ensuring stem cell safety in regenerative medicine.
  • Monitoring therapeutic cell behavior and suicide gene expression in vivo is crucial for efficacy and safety.

Purpose of the Study:

  • To develop multimodal imaging approaches for noninvasive, longitudinal monitoring of therapeutic cells expressing suicide genes.
  • To enable early detection of therapeutic cell location, viability, and initiation of cell suicide.

Main Methods:

  • Engineering therapeutic cells to express suicide genes and genes for in vivo visualization.
  • Utilizing multimodal imaging techniques to track cell location, viability, and gene expression.

Main Results:

  • Demonstrated examples of modified therapeutic cells for in vivo tracking and suicide gene expression.
  • Highlighted the necessity of imaging for monitoring cell infiltration and teratoma formation.

Conclusions:

  • Multimodal in vivo imaging is essential for advancing suicide gene therapy and regenerative medicine applications.
  • Noninvasive imaging provides critical data for ensuring the safety and effectiveness of cell-based therapies.
Keywords:
Bioluminescence imagingMagnetic resonance imagingPositron emission tomographyStem cellsSuicide gene

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