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Functional magnetic resonance imaging with encoding task in patients with mild cognitive impairment and different

Alberto Chiti1, Paolo Cecchi2, Ilaria Pesaresi2

  • 1Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa 56126, Italy; Unit of Neurology, Ospedale Apuane, Via Mattei 21, Massa 54100, Italy.

Psychiatry Research. Neuroimaging
|December 13, 2018
PubMed

Insights

Functional MRI reveals distinct brain activation patterns in vascular mild cognitive impairment (VMCI). VMCI patients show altered activity in specific cortical regions compared to non-vascular MCI and healthy controls.

Area of Science:

  • Neuroimaging
  • Neurology
  • Cognitive Science

Background:

  • Leukoaraiosis is a key factor in vascular mild cognitive impairment (VMCI).
  • The exact pathophysiology of VMCI remains unclear.
  • Functional MRI (fMRI) offers insights into brain function.

Purpose of the Study:

  • To investigate the brain's functional changes in VMCI using fMRI.
  • To differentiate VMCI from non-vascular MCI (NVMCI) and healthy controls (HC).

Main Methods:

  • fMRI scans were performed on 16 VMCI patients, 25 NVMCI patients, and 15 HC.
  • An incidental verbal learning paradigm was used during fMRI acquisition.
  • A 3T MRI scanner was utilized for all participants.

Main Results:

  • VMCI patients exhibited increased BOLD activation in the right parieto-occipital cortex compared to HC.
  • VMCI patients showed decreased activation in left frontal and fronto-opercular areas versus HC.
  • NVMCI patients did not show the same activation patterns as VMCI when compared to HC.

Conclusions:

  • fMRI-assessed cortical activation patterns may indicate specific brain damage in VMCI.
  • Altered brain activity in VMCI could reflect compensatory mechanisms.
  • These findings contribute to understanding VMCI pathophysiology related to leukoaraiosis severity.
Keywords:
DementiaFunctional magnetic resonance imagingLeukoaraiosisMild cognitive impairment

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