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Updated: Feb 1, 2026

Preparing T Cell Growth Factor from Rat Splenocytes
Published on: October 31, 2007
Diverse effects of platelet-derived growth factor-BB on cell signaling pathways
Chenbing Wang1, Yanbo Liu1, Dongning He1
1Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, China.
Abstract:
Platelet-derived growth factor-BB (PDGF-BB) is involved in the tissue repair and tumor progression effects, and act as a rapid and early effector cytokines which are released in response to pathogen-induced changes in the microenvironment. Recent researches have implicated PDGF-BB as a potential contributing factor to the spectrum of the cell signaling pathway of interrelated diseases, particularly mesangial cells, mesenchymal stem cells, human dermal fibroblasts, tumor pericytes and smooth muscle cells. In this review, we generalize the present literatures on the roles of PDGF-BB in the various interrelated diseases, providing insights or strategies into the underlying cellular and signaling mechanisms that will help guide future studies further into promising interventional targets with therapeutic potential.
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