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Related Experiment Video

Updated: Feb 1, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

Dynamic split G-quadruplex programmed reversible nanodevice.

Yanyan Yu¹, Yao Zhou, Min Zhu

¹School of pharmacy, Nantong University, Nantong 226001, Jiangsu Province, China. sugaoxing@ntu.edu.cn.

Chemical Communications (Cambridge, England)

|December 13, 2018

Summary

We developed a novel dynamic nanodevice using a split G-quadruplex (G4). This design decouples G4 formation from stimuli, enabling reversible switching via conformational changes for broader applications.

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Area of Science:

Molecular nanotechnology
Biomolecular engineering

Background:

G-quadruplexes (G4) are G-rich nucleic acid structures with potential in nanotechnology.
Current G4-based devices often have limited stimulus responsiveness.

Purpose of the Study:

To engineer a dynamic nanodevice utilizing a split G-quadruplex (G4) structure.
To expand the range of stimuli that can control G4-based nanodevices.

Main Methods:

Designing a split G-quadruplex (G4) nanodevice.
Utilizing DNA duplexes to provide structural rigidity and control conformational changes.
Investigating reversible switching mechanisms.

Main Results:

Successfully decoupled G-tetrad formation from external stimuli.
Demonstrated reversible switching of the nanodevice through conformational transformation.
Expanded the potential stimuli for G4-based device applications.

Conclusions:

The split G-quadruplex (G4) nanodevice offers enhanced control and expanded stimulus options.
This approach provides a versatile platform for developing novel dynamic nanodevices.
The nanodevice's reversible switching mechanism opens new avenues in molecular nanotechnology.