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Updated: Feb 1, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
[Relationship between sepsis-induced immunosuppression and multi-drugs resistant bacteria]
Gengxin Cai1, Jingkun Ye, Miaoyun Wen
1Guangdong Provincial General Hospital, South China University of Technology, Guangzhou 510006, Guangdong, China (Cai GX); Second Clinical Medical College of Southern Medical University, Guangzhou 510515, Guangdong, China (Ye JK); Department of Emergency and Critical Care Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China (Wen MY). Corresponding author: Wen Miaoyun,
Objective:
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. Immunosuppression is an important factor of secondary infection in the late state of sepsis, including multi-drugs resistant bacteria, which ultimately leads to the death of patients. The aim of this article was to help clinical staffs better manage patients with sepsis, improve long-term survival rate of the patients, and reduce their re-hospitalization rate by reviewing the relationship between sepsis-induced immunosuppression and multi-drugs resistant bacteria through three aspects: the mechanism of sepsis-induced immunosuppression, the mechanism of antibiotic resistance and the relationship between sepsis-induced immunosuppression and secondary infections.
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