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Experience-Dependent Intrinsic Plasticity During Auditory Learning.

Matthew T Ross1,2, Diana Flores3, Richard Bertram1,3

  • 1Program in Neuroscience.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|December 14, 2018
PubMed
Summary
This summary is machine-generated.

Song learning in zebra finches depends on auditory exposure. Juvenile HVC neurons show experience-dependent changes in intrinsic physiology, with tutor deprivation leading to an adult-like phenotype, suggesting intrinsic plasticity in vocal learning.

Keywords:
auditory learningbirdsongintrinsic plasticityion channelsmodelingzebra finch

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Area of Science:

  • Neuroscience
  • Animal Behavior
  • Developmental Biology

Background:

  • Song learning in zebra finches requires auditory exposure to a tutor song, forming auditory memory.
  • The HVC (proper name) nucleus is crucial for auditory learning, sensorimotor processing, and adult song production.
  • Previous work showed HVC neuron physiology changes during song learning, but the role of auditory experience was unclear.

Purpose of the Study:

  • To determine if auditory experience drives intrinsic physiological changes in HVC neurons during song learning.
  • To investigate the impact of tutor exposure levels on HVC neuron intrinsic properties in juvenile zebra finches.

Main Methods:

  • Patch-clamp electrophysiology was used to compare HVC neurons from juvenile zebra finches with varying tutor song exposure.
  • Biophysical modeling was employed to predict the ion channels modulated by auditory experience.

Main Results:

  • HVC neuron intrinsic physiology varied significantly with the amount of tutor song exposure.
  • Tutor-deprived juvenile birds exhibited an adult-like HVC neuron phenotype, unlike tutor-exposed juveniles.
  • Models suggested experience-dependent suppression of Ih and T-type Ca2+ currents, and altered resting potential and spike amplitude.

Conclusions:

  • Auditory experience actively shapes the intrinsic physiology of HVC neurons during vocal learning.
  • Intrinsic plasticity, potentially involving ion channel modulation, may be a key mechanism in auditory learning.
  • These findings suggest that models of learning and memory should incorporate intrinsic neuronal plasticity.