Related Experiment Video

Updated: Feb 1, 2026

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
14:04

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

15.8K

Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma

Yoshihiro Komohara, Osamu Noyori, Yoichi Saito

    Journal of Clinical and Experimental Hematopathology : JCEH
    |December 14, 2018
    PubMed

    Insights

    Macrophage colony stimulating factor receptor (M-CSFR) is overexpressed in adult T-cell leukemia/lymphoma (ATLL). Inhibiting M-CSFR suppressed lymphoma cell growth and induced apoptosis, suggesting its potential as an ATLL therapy.

    Area of Science:

    • Oncology
    • Immunology
    • Molecular Biology

    Background:

    • The c-fms proto-oncogene, known as macrophage colony stimulating factor receptor (M-CSFR) or colony-stimulating factor-1 receptor (CSF-1R), is expressed on malignant tumor and myeloid cells.
    • M-CSFR signaling plays a role in cell proliferation and survival.

    Purpose of the Study:

    • To investigate the role of M-CSFR in adult T-cell leukemia/lymphoma (ATLL).
    • To evaluate the therapeutic potential of M-CSFR inhibition in ATLL.

    Main Methods:

    • Analysis of M-CSFR expression in ATLL cases.
    • Assessment of M-CSFR ligand (M-CSF/CSF-1 and IL-34) expression in ATLL cell lines and patient samples.
    • Evaluation of M-CSFR inhibition effects on lymphoma cell proliferation, apoptosis, and ligand expression.

    Main Results:

    • M-CSFR was overexpressed in ATLL cases.
    • M-CSFR signaling was linked to lymphoma cell proliferation.
    • M-CSFR inhibition led to apoptosis in lymphoma cells.
    • M-CSFR inhibition suppressed programmed death-1 and -2 ligand expression.

    Conclusions:

    • M-CSFR is a potential therapeutic target in ATLL.
    • M-CSFR inhibition may offer direct and indirect anti-tumor effects in ATLL.
    • Targeting M-CSFR could be a valuable addition to ATLL treatment strategies.
    Keywords:
    ATLLCSF-1RM-CSFRPD-L1macrophage

    More Related Videos

    Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma10:52

    Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

    Published on: March 30, 2018

    11.7K
    Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma08:31

    Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

    Published on: September 12, 2025

    818

    Related Concept Videos

    Adult Stem Cells01:33

    Adult Stem Cells

    Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
    33.9K
    Cell Potential and Free Energy02:58

    Cell Potential and Free Energy

    Thermodynamics of a Redox Reaction
    Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
    Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
    46.5K
    Eukaryotic Transcription Inhibitors01:52

    Eukaryotic Transcription Inhibitors

    Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
    Eukaryotic transcription inhibitors usually contain two distinct domains, a...
    11.0K
    Potential Energy00:52

    Potential Energy

    The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
    Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
    42.7K
    The Resting Membrane Potential01:21

    The Resting Membrane Potential

    Overview
    142.5K
    Standard Electrode Potentials03:02

    Standard Electrode Potentials

    On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
    50.3K