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Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases
Reto Guler1,2,3, Thabo Mpotje1,2, Mumin Ozturk1,2
1International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, 7925, South Africa.
Mucosal Immunology
|December 14, 2018
Summary
Basic leucine zipper transcription factor 2 (Batf2) is harmful in Type 1 infections like tuberculosis but beneficial in Type 2 infections like schistosomiasis. Batf2 deficiency improves survival in Type 1 infections while worsening Type 2.
Area of Science:
- Immunology
- Molecular Biology
- Infectious Diseases
Background:
- Basic leucine zipper transcription factor 2 (Batf2) plays a role in immune responses.
- Its precise function in different types of infectious diseases is not fully understood.
Purpose of the Study:
- To investigate the differential role of Batf2 in Type 1 and Type 2 controlled infectious diseases.
- To determine the impact of Batf2 deficiency on host survival and pathology during Mycobacterium tuberculosis (Mtb) and Listeria monocytogenes (Lm) infections, as well as schistosomiasis.
Main Methods:
- Utilized Batf2-deficient (Batf2-/-) mice and wild-type controls.
- Infected mice with Mtb, Lm, and Schistosoma parasites.
- Assessed survival rates, tissue pathology, inflammatory markers, cytokine production, and immune cell recruitment.
Main Results:
- Batf2 deficiency improved survival and reduced pathology in Mtb and Lm infections (Type 1).
- Batf2 deficiency exacerbated disease severity, leading to increased inflammation and early death in schistosomiasis (Type 2).
- Batf2 expression was upregulated during Mtb and Lm infections in relevant tissues and cell types.
Conclusions:
- Batf2 differentially regulates Type 1 and Type 2 immune responses in infectious diseases.
- Targeting Batf2 could be a potential therapeutic strategy, with outcomes depending on the type of infection.
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